News Details
Soft capsules use antioxidants
2018-1-7 20:05:47
Soft capsules use antioxidants
From the preparation aspect, it is considered to prevent the oxidative reaction of the drug, especially the vitamin, which can be affected by temperature, oxygen and heavy metals, which can be made into soft capsules. Soft capsules are made of gelatin and glycerin, and the wall is thick and breathless, which is a good preparation for preventing the oxidation of drugs.
But often contain preservatives, fatty substances within soft capsule and polyethylene compounds, such as polyethylene glycol, polyethylene glycol ether, fatty alcohol or phenol, polyoxyethylene glyceride and non ionic and nonionic surfactant (twain, unsaturated fatty acid ester, etc.), these compounds will happen since the oxidation reaction, formation of larger molecular weight of aldehyde, which gave birth to clinch a deal that could react with the gelatin products results in the decrease of in vitro dissolution rate, slow disintegration.
In the preparation of soft capsule, a moderate amount of soft capsule was added with antioxygenation. The anti-oxygen agent of soft capsule could significantly delay the aging speed of gelatin and improve the stability of pharmaceutical preparations.
Testing soft capsule with antioxidant 2, 6 - BHT (butylated hydroxytoluene) of HPLC, and the detection methods of linearity, repeatability and accuracy of inspection, the results show that the detection method is sensitive, accurate and reproducible, and can effectively control the quality of the product.
BHT, which is commonly known as BHT, is an oil soluble organic compound. It is mainly used as an antioxidant in food additives (E coded as E321). It also has antioxidant properties in cosmetics, drugs, aircraft fuel, rubber, petroleum products and specimens.
2, 6-2 tert-butyl (BHT) GB 1900-80. This standard is applicable to the preparation of cresol - isobutanol as the raw material, with concentrated sulfuric acid as the catalyst, alumina as dehydrating agent, and the reaction of the reaction is 2.6. Used as an antioxidant in food processing.
Bhtwas patented in 1947. In 1954, the food and drug administration (FDA) allowed food to be added to BHT to keep it fresh.
BHT and free radicals produce chemical reactions and slow the rate of oxidation and reduction reactions in food (i.e., acid failure reactions). This keeps the food color, smell, and taste.
White crystallization, light yellow, and gradually darker. Soluble in benzene, toluene, methanol, methyl ethyl ketone, ethanol, isopropanol, petroleum ether, flaxseed oil, insoluble in water and 10 ℃ caustic soda solution.
Triphenyl phosphite (antioxidant, stabilizer TPPi) production process
1. Phosphorus oxychloride as the direct method (also called thermal method) phenol with pyridine and anhydrous benzene as solvent, in no more than 10 ℃ temperature, slowly add oxygen phosphorus chloride, then under reflux temperature, the reaction of 3 ~ 4 h. After cooling to room temperature, the reactants are washed by water to recycle pyridine. After centrifugal dehydration, the reagents are dehydrated with dried sodium sulfate, which is filtered to remove sodium sulfate. The first atmospheric distillation recovery of benzene, vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fraction, by cooling, crystallization, crushing is the finished product.
2. After phenol melting, stirring under add phosphorus trichloride under 25 ℃, Triphenyl phosphite is generated; Then heat up to 70 ℃ ventilation with chlorine gas, generated two chlorinated triphenyl phosphate; Again at 50 ℃ water hydrolysis, triphenyl phosphate. The hydrolysate with 5% soda solution for neutralization, water washing, the evaporation and vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fractions, cooling, crystallization, crushing, packaging is the finished product.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
BHT can also be added to the production of certain substances, such as tetrahydrofuran and ethyl ether, to avoid harmful peroxide organic compounds.
Related compound BHA.
Used for organic synthesis, used as an antioxidant of rubber, plastic anti-aging agent, gasoline, transformer oil, turbine oil, animal and vegetable oil, food, etc.
2, 6-dibasic is a widely used oil-soluble antioxidant in China and abroad. A great toxicity, but its antioxidant ability is stronger, heat resistance and good stability, no peculiar smell, no color reaction with metal ions such as faults, and the price is low, only 1/5 ~ 1/8 for BHA, our country is still used as the main antioxidant. It is commonly used in conjunction with BHA, with citric acid or other organic acids as synergistic agents. China can be used for edible oil, Fried food, biscuits, instant noodles, boiled rice, nut can, dried fish products and preserved meat products, with the maximum use of 0.2g/kg. This product also has certain antibacterial effect, but is weaker than BHA
2, 6-2 tert-butyl is used as a feed antioxidant to protect the vitamins in the feed, preventing the oxidative loss of fat and protein. Also have certain antibacterial action. The maximum dosage is 150g/t.
It is widely used in polymer materials, petroleum products and food processing industry. This product is a commonly used rubber anti-aging agent. It has protective effect on heat and oxygen aging, and can also inhibit copper damage. Use no ozone resistance alone, but with antiozonant and waxes and the various factors that protect the weather of the weather. It can also be used as a gel inhibitor in butadiene adhesive. The normal amount of rubber is 0.5-3. When the dosage increases to 3-5, no frost. This product can also be used as a stabilizer for the processing and storage of synthetic rubber, which can be used in the rubber such as styrene butadiene rubber, shuntin rubber, ethylene propylene rubber and chloroprene rubber. Antioxidant 264 is an effective antioxidant in some high polymer materials. This product is an effective stabilizer in polyethylene, polyvinyl chloride (0.01-0.1%) and polyvinyl ether.
2, 6-dibasic is mainly used for edible oil and dried fish products. The most commonly used food antioxidants are phenolic substances. Of antioxidants BHA (BHA), butylated hydroxytoluene (butylated hydroxy toluene), PG (gallic acid ester c), TBHQ (TBHQ) and five kinds of tocopherol is widespread use of antioxidants in the world, they can be used alone or in combination with citric acid, ascorbic acid, such as acid synergist, when used in combination to meet the needs of most of the food products.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
From the preparation aspect, it is considered to prevent the oxidative reaction of the drug, especially the vitamin, which can be affected by temperature, oxygen and heavy metals, which can be made into soft capsules. Soft capsules are made of gelatin and glycerin, and the wall is thick and breathless, which is a good preparation for preventing the oxidation of drugs.
But often contain preservatives, fatty substances within soft capsule and polyethylene compounds, such as polyethylene glycol, polyethylene glycol ether, fatty alcohol or phenol, polyoxyethylene glyceride and non ionic and nonionic surfactant (twain, unsaturated fatty acid ester, etc.), these compounds will happen since the oxidation reaction, formation of larger molecular weight of aldehyde, which gave birth to clinch a deal that could react with the gelatin products results in the decrease of in vitro dissolution rate, slow disintegration.
In the preparation of soft capsule, a moderate amount of soft capsule was added with antioxygenation. The anti-oxygen agent of soft capsule could significantly delay the aging speed of gelatin and improve the stability of pharmaceutical preparations.
Testing soft capsule with antioxidant 2, 6 - BHT (butylated hydroxytoluene) of HPLC, and the detection methods of linearity, repeatability and accuracy of inspection, the results show that the detection method is sensitive, accurate and reproducible, and can effectively control the quality of the product.
BHT, which is commonly known as BHT, is an oil soluble organic compound. It is mainly used as an antioxidant in food additives (E coded as E321). It also has antioxidant properties in cosmetics, drugs, aircraft fuel, rubber, petroleum products and specimens.
2, 6-2 tert-butyl (BHT) GB 1900-80. This standard is applicable to the preparation of cresol - isobutanol as the raw material, with concentrated sulfuric acid as the catalyst, alumina as dehydrating agent, and the reaction of the reaction is 2.6. Used as an antioxidant in food processing.
Bhtwas patented in 1947. In 1954, the food and drug administration (FDA) allowed food to be added to BHT to keep it fresh.
BHT and free radicals produce chemical reactions and slow the rate of oxidation and reduction reactions in food (i.e., acid failure reactions). This keeps the food color, smell, and taste.
White crystallization, light yellow, and gradually darker. Soluble in benzene, toluene, methanol, methyl ethyl ketone, ethanol, isopropanol, petroleum ether, flaxseed oil, insoluble in water and 10 ℃ caustic soda solution.
Triphenyl phosphite (antioxidant, stabilizer TPPi) production process
1. Phosphorus oxychloride as the direct method (also called thermal method) phenol with pyridine and anhydrous benzene as solvent, in no more than 10 ℃ temperature, slowly add oxygen phosphorus chloride, then under reflux temperature, the reaction of 3 ~ 4 h. After cooling to room temperature, the reactants are washed by water to recycle pyridine. After centrifugal dehydration, the reagents are dehydrated with dried sodium sulfate, which is filtered to remove sodium sulfate. The first atmospheric distillation recovery of benzene, vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fraction, by cooling, crystallization, crushing is the finished product.
2. After phenol melting, stirring under add phosphorus trichloride under 25 ℃, Triphenyl phosphite is generated; Then heat up to 70 ℃ ventilation with chlorine gas, generated two chlorinated triphenyl phosphate; Again at 50 ℃ water hydrolysis, triphenyl phosphate. The hydrolysate with 5% soda solution for neutralization, water washing, the evaporation and vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fractions, cooling, crystallization, crushing, packaging is the finished product.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
BHT can also be added to the production of certain substances, such as tetrahydrofuran and ethyl ether, to avoid harmful peroxide organic compounds.
Related compound BHA.
Used for organic synthesis, used as an antioxidant of rubber, plastic anti-aging agent, gasoline, transformer oil, turbine oil, animal and vegetable oil, food, etc.
2, 6-dibasic is a widely used oil-soluble antioxidant in China and abroad. A great toxicity, but its antioxidant ability is stronger, heat resistance and good stability, no peculiar smell, no color reaction with metal ions such as faults, and the price is low, only 1/5 ~ 1/8 for BHA, our country is still used as the main antioxidant. It is commonly used in conjunction with BHA, with citric acid or other organic acids as synergistic agents. China can be used for edible oil, Fried food, biscuits, instant noodles, boiled rice, nut can, dried fish products and preserved meat products, with the maximum use of 0.2g/kg. This product also has certain antibacterial effect, but is weaker than BHA
2, 6-2 tert-butyl is used as a feed antioxidant to protect the vitamins in the feed, preventing the oxidative loss of fat and protein. Also have certain antibacterial action. The maximum dosage is 150g/t.
It is widely used in polymer materials, petroleum products and food processing industry. This product is a commonly used rubber anti-aging agent. It has protective effect on heat and oxygen aging, and can also inhibit copper damage. Use no ozone resistance alone, but with antiozonant and waxes and the various factors that protect the weather of the weather. It can also be used as a gel inhibitor in butadiene adhesive. The normal amount of rubber is 0.5-3. When the dosage increases to 3-5, no frost. This product can also be used as a stabilizer for the processing and storage of synthetic rubber, which can be used in the rubber such as styrene butadiene rubber, shuntin rubber, ethylene propylene rubber and chloroprene rubber. Antioxidant 264 is an effective antioxidant in some high polymer materials. This product is an effective stabilizer in polyethylene, polyvinyl chloride (0.01-0.1%) and polyvinyl ether.
2, 6-dibasic is mainly used for edible oil and dried fish products. The most commonly used food antioxidants are phenolic substances. Of antioxidants BHA (BHA), butylated hydroxytoluene (butylated hydroxy toluene), PG (gallic acid ester c), TBHQ (TBHQ) and five kinds of tocopherol is widespread use of antioxidants in the world, they can be used alone or in combination with citric acid, ascorbic acid, such as acid synergist, when used in combination to meet the needs of most of the food products.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
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