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Natural antioxidant
2017-12-30 18:31:44
Natural antioxidant
There are many kinds of natural antioxidants. At present, there are hundreds of natural substances that have antioxidant activity. But there are not many natural antioxidants approved, including vitamin E, tea polyphenols, phytic acid and so on.
Natural antioxidant vitamin E also known as tocopherol, is one of the earliest people found that vitamin, natural tocopherol and tocopherol compounds is three ene tocopherols and more or less general display d- activity of alpha tocopherol derivatives, vitamin E belongs to phenolic compounds, the chroman ring is sixth hydroxyl reactive groups, can release active the hydroxyl hydrogen, capture free radicals, thereby blocking free radical chain reaction. In addition, the O-C bond can be broken through the tocopherol free radical oxygen complex naphthalene, and the free radical can be removed directly by combining with OH. As a result, natural vitamin E is a strong and effective antioxidant and is widely used in the food and pharmaceutical industry.
Vitamin E (Vitamin E) is a fat soluble vitamin, and its hydrolysate is tocopherol. It is one of the most important antioxidants. Soluble in organic solvents such as fat and ethanol, it is insoluble in water, stable in heat and acid, unstable in alkali, sensitive to oxygen and insensitive to heat, but vitamin E activity is reduced significantly during frying. Tocopherol can promote hormone secretion, make sperm motility and increase in the number; the women's estrogen levels, improve fertility, prevent miscarriage, also can be used for the prevention and treatment of male infertility, burns, frostbite, capillary hemorrhage, climacteric syndrome, beauty and other aspects. Recently, vitamin E has also been found to inhibit the lipid peroxidation in the crystalline form of the eye, expand the peripheral vessels, improve the blood circulation and prevent the occurrence and development of myopia. The phenolic hydroxyl group on the vitamin E benzene ring is acetylation, and the ester is hydrolyzed to phenol hydroxyl group, then it is tocopherol. It is often mistaken for vitamin E to be tocopherol.
Vitamin E is a fat soluble vitamin in 8 forms and is an important antioxidant. Vitamin E includes tocopherols and three ene tocopherol two kinds of 8 compounds, namely, alpha, beta, gamma, delta tocopherol and alpha, beta, gamma, delta three ene tocopherol, alpha tocopherol is the most widely distributed, the most abundant and the most active form of vitamin E in nature.
Vitamin E has anti-oxidation effect is very stable to heat, acid, alkaline instability, if the lead salts, salt or oil rancidity conditions, will accelerate the oxidation and destruction.
Tocopherol has four main derivatives, which are divided into four kinds, namely, alpha, beta, gamma and delta according to the methyl position. The activity of three alkenols related to tocopherol in the substituent group is certain, but the activity of tocopherol can be significantly reduced.
Determination of vitamin E - gas chromatography. The principle of the method is to prepare methanol solution for the test and internal standard, to enter the gas chromatograph, to separate and detect the absorption value of vitamin E (C31H52O3) and internal standard thirty-two alkane, and calculate its content.
Triphenyl phosphite (antioxidant, stabilizer TPPi) production process
1. Phosphorus oxychloride as the direct method (also called thermal method) phenol with pyridine and anhydrous benzene as solvent, in no more than 10 ℃ temperature, slowly add oxygen phosphorus chloride, then under reflux temperature, the reaction of 3 ~ 4 h. After cooling to room temperature, the reactants are washed by water to recycle pyridine. After centrifugal dehydration, the reagents are dehydrated with dried sodium sulfate, which is filtered to remove sodium sulfate. The first atmospheric distillation recovery of benzene, vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fraction, by cooling, crystallization, crushing is the finished product.
2. After phenol melting, stirring under add phosphorus trichloride under 25 ℃, Triphenyl phosphite is generated; Then heat up to 70 ℃ ventilation with chlorine gas, generated two chlorinated triphenyl phosphate; Again at 50 ℃ water hydrolysis, triphenyl phosphate. The hydrolysate with 5% soda solution for neutralization, water washing, the evaporation and vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fractions, cooling, crystallization, crushing, packaging is the finished product.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
Reagent: hexane. Instrument and equipment: instrument gas chromatograph. Column: silicone (OV-17) as the stationary phase, the coating concentration is 2%, or by HP-1 capillary column (100% two methyl siloxane) column; the number of theoretical plates calculated with vitamin E peak is not less than 500 (packed column) or 5000 (Mao Xiguanzhu), vitamin E and internal standard substance separation peak peak shall comply with the requirements.
Tea polyphenols are unique polyphenolic compounds in tea, including catechin, flavonoids, anthocyanins, phenolic acids, and other 4 major substances. Tea polyphenol is a natural strong antioxidant, has superior antioxidant capacity, and has anti-cancer, anti-aging, anti radiation, scavenging free radicals, reducing blood glucose, reducing blood pressure, reducing blood lipid and sterilization etc. a series of pharmacological functions, and has wide application prospect in the fields of medicine, food and beverage. Tea polyphenols, as a strong antioxidant, act directly on free radicals by blocking the activities of enzymes related to free radicals and inhibiting their activities, blocking the free radical chain reaction and exerting their antioxidant effects.
Tea polyphenols, a polycyclic aromatic hydrocarbon, can be divided into flavanols, hydroxy -[4]- flavanols, anthocyanins, flavonoids, flavonoids, alcohols and phenolic acids. Among them, catechin is the most important, accounting for about 60%-80% of the total polyphenols; catechin mainly consists of EGC, DLC, EC, EGCG, GCG, ECG and other monomers.
The content of tea polyphenols in tea is usually 20 - 35%. The flavanols are the main components of the tea polyphenols, and the flavanols are mainly catechin. The content of catechin is about 70% of the total amount of tea polyphenols.
The scientific name of phytic acid is cyclohexanol six phosphate six phosphate. It is a kind of vitamin B family of inositol six phosphate. It is soluble in water, methanol, ethanol, acetone and other polar solvents. It has 12 dissociated acid hydrogen ions. Phytic acid is strong acidic and has strong complexing ability. This characteristic determines that phytic acid has wide application prospects in the food and pharmaceutical industry. In phytate and pharmaceutical industry, phytic acid is used as antioxidant, which not only can extend the shelf life of products, but also inhibit the growth of microorganisms.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
There are many kinds of natural antioxidants. At present, there are hundreds of natural substances that have antioxidant activity. But there are not many natural antioxidants approved, including vitamin E, tea polyphenols, phytic acid and so on.
Natural antioxidant vitamin E also known as tocopherol, is one of the earliest people found that vitamin, natural tocopherol and tocopherol compounds is three ene tocopherols and more or less general display d- activity of alpha tocopherol derivatives, vitamin E belongs to phenolic compounds, the chroman ring is sixth hydroxyl reactive groups, can release active the hydroxyl hydrogen, capture free radicals, thereby blocking free radical chain reaction. In addition, the O-C bond can be broken through the tocopherol free radical oxygen complex naphthalene, and the free radical can be removed directly by combining with OH. As a result, natural vitamin E is a strong and effective antioxidant and is widely used in the food and pharmaceutical industry.
Vitamin E (Vitamin E) is a fat soluble vitamin, and its hydrolysate is tocopherol. It is one of the most important antioxidants. Soluble in organic solvents such as fat and ethanol, it is insoluble in water, stable in heat and acid, unstable in alkali, sensitive to oxygen and insensitive to heat, but vitamin E activity is reduced significantly during frying. Tocopherol can promote hormone secretion, make sperm motility and increase in the number; the women's estrogen levels, improve fertility, prevent miscarriage, also can be used for the prevention and treatment of male infertility, burns, frostbite, capillary hemorrhage, climacteric syndrome, beauty and other aspects. Recently, vitamin E has also been found to inhibit the lipid peroxidation in the crystalline form of the eye, expand the peripheral vessels, improve the blood circulation and prevent the occurrence and development of myopia. The phenolic hydroxyl group on the vitamin E benzene ring is acetylation, and the ester is hydrolyzed to phenol hydroxyl group, then it is tocopherol. It is often mistaken for vitamin E to be tocopherol.
Vitamin E is a fat soluble vitamin in 8 forms and is an important antioxidant. Vitamin E includes tocopherols and three ene tocopherol two kinds of 8 compounds, namely, alpha, beta, gamma, delta tocopherol and alpha, beta, gamma, delta three ene tocopherol, alpha tocopherol is the most widely distributed, the most abundant and the most active form of vitamin E in nature.
Vitamin E has anti-oxidation effect is very stable to heat, acid, alkaline instability, if the lead salts, salt or oil rancidity conditions, will accelerate the oxidation and destruction.
Tocopherol has four main derivatives, which are divided into four kinds, namely, alpha, beta, gamma and delta according to the methyl position. The activity of three alkenols related to tocopherol in the substituent group is certain, but the activity of tocopherol can be significantly reduced.
Determination of vitamin E - gas chromatography. The principle of the method is to prepare methanol solution for the test and internal standard, to enter the gas chromatograph, to separate and detect the absorption value of vitamin E (C31H52O3) and internal standard thirty-two alkane, and calculate its content.
Triphenyl phosphite (antioxidant, stabilizer TPPi) production process
1. Phosphorus oxychloride as the direct method (also called thermal method) phenol with pyridine and anhydrous benzene as solvent, in no more than 10 ℃ temperature, slowly add oxygen phosphorus chloride, then under reflux temperature, the reaction of 3 ~ 4 h. After cooling to room temperature, the reactants are washed by water to recycle pyridine. After centrifugal dehydration, the reagents are dehydrated with dried sodium sulfate, which is filtered to remove sodium sulfate. The first atmospheric distillation recovery of benzene, vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fraction, by cooling, crystallization, crushing is the finished product.
2. After phenol melting, stirring under add phosphorus trichloride under 25 ℃, Triphenyl phosphite is generated; Then heat up to 70 ℃ ventilation with chlorine gas, generated two chlorinated triphenyl phosphate; Again at 50 ℃ water hydrolysis, triphenyl phosphate. The hydrolysate with 5% soda solution for neutralization, water washing, the evaporation and vacuum distillation, collected 243 ~ 245 ℃ (1.47 kPa) fractions, cooling, crystallization, crushing, packaging is the finished product.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
Reagent: hexane. Instrument and equipment: instrument gas chromatograph. Column: silicone (OV-17) as the stationary phase, the coating concentration is 2%, or by HP-1 capillary column (100% two methyl siloxane) column; the number of theoretical plates calculated with vitamin E peak is not less than 500 (packed column) or 5000 (Mao Xiguanzhu), vitamin E and internal standard substance separation peak peak shall comply with the requirements.
Tea polyphenols are unique polyphenolic compounds in tea, including catechin, flavonoids, anthocyanins, phenolic acids, and other 4 major substances. Tea polyphenol is a natural strong antioxidant, has superior antioxidant capacity, and has anti-cancer, anti-aging, anti radiation, scavenging free radicals, reducing blood glucose, reducing blood pressure, reducing blood lipid and sterilization etc. a series of pharmacological functions, and has wide application prospect in the fields of medicine, food and beverage. Tea polyphenols, as a strong antioxidant, act directly on free radicals by blocking the activities of enzymes related to free radicals and inhibiting their activities, blocking the free radical chain reaction and exerting their antioxidant effects.
Tea polyphenols, a polycyclic aromatic hydrocarbon, can be divided into flavanols, hydroxy -[4]- flavanols, anthocyanins, flavonoids, flavonoids, alcohols and phenolic acids. Among them, catechin is the most important, accounting for about 60%-80% of the total polyphenols; catechin mainly consists of EGC, DLC, EC, EGCG, GCG, ECG and other monomers.
The content of tea polyphenols in tea is usually 20 - 35%. The flavanols are the main components of the tea polyphenols, and the flavanols are mainly catechin. The content of catechin is about 70% of the total amount of tea polyphenols.
The scientific name of phytic acid is cyclohexanol six phosphate six phosphate. It is a kind of vitamin B family of inositol six phosphate. It is soluble in water, methanol, ethanol, acetone and other polar solvents. It has 12 dissociated acid hydrogen ions. Phytic acid is strong acidic and has strong complexing ability. This characteristic determines that phytic acid has wide application prospects in the food and pharmaceutical industry. In phytate and pharmaceutical industry, phytic acid is used as antioxidant, which not only can extend the shelf life of products, but also inhibit the growth of microorganisms.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
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