Ketimine coating crosslinking agent

Ketimine coating crosslinking agent,Ketimine crosslinking agent is reaction with multiple amine ketone was the product of the use of ketone imide class crosslinking agent can be made into wet conditions and underwater crosslinked coating.

Ketimine consists of ketone (such as methyl ethyl ketone, methyl isopropyl ketone and methyl isobutyl ketone) with multiple amine [such as diethylene triamine, m-phenylene diamine, between benzene dimethylamine and 1, 3 - (aminomethyl) cyclohexane, etc.] made by the condensation reaction, the residual multiple amine must use single epoxy compound closed.

Ketimine adverse reaction occurred after absorbing moisture, generating multiple amine, therefore can be in damp or underwater cross-linked epoxy resin, therefore calls moist crosslinking agent. One of ketimine products, double - N, N '- (methyl - butyl phosphite) - divinyl three amine is divinyl three amine and methyl isobutyl ketone condensation compound, the molecular weight of 267.45. Light yellow liquid, the smell of ammonia. Viscosity of 25 ~ 30 mpa. S. Stable at room temperature.

Used as a crosslinking agent of epoxy resin adhesives, reference dose of 20 ~ 40, moisture/duplicate components can be produced, epoxy adhesives crosslinking conditions / 24 ~ 48 h at room temperature. Research shows that methyl isopropyl ketone (MIPK) and methyl isobutyl ketone (MIBK) and 1, 3-2 (aminomethyl) cyclohexane (1, 3 - BAC) reaction of ketone imide, its storage stability and crosslinking reaction are ideal.

With polyether modified aliphatic amine diversity and methyl isobutyl ketone condensation and ketone imide, type latent epoxy resin is a kind of the good performance of crosslinking agent, with its mixture of one-component epoxy adhesive, improved the toughness and elongation at break of up to 150%, and stick relay is strong. Also used as a potential one-component polyurethane adhesives moisture crosslinking agent.

Ketimine active substances such as suitable for the preparation of drug resistant sertraline depressive quality raw materials. Preparation ketone imide method of characteristics is ketone and methylamine in aprotic solvent such as tetrahydrofuran in titanium tetrachloride reaction and cooling conditions. Disadvantage of this method is that you must use the flammable tetrahydrofuran and potentially harmful to the environment of titanium tetrachloride. Because of the reaction under cooling conditions, the method of cost is expensive. Another drawback of this method is the post-processing. Product must be also in hexane precipitation.

Make ketone with anhydrous methylamine in aprotic solvent such as methylene chloride, toluene or tetrahydrofuran exist in a molecular sieve reaction and cooling conditions. The shortcoming of this method is that they must be used without water and may be harmful to the environment of solvent such as methylene chloride or flammable solvents such as tetrahydrofuran operation. The molecular sieve used relatively expensive, must be in an additional step of recycling. Another drawback of this method is a product must be separation of molecular sieve and the other in hexane precipitation.




Chinese name: Diethyl toluene diamine(DETDA)

Diethyltoluenediamine packing： net weight 200KG/ galvanized iron drum (a small cabinet pallet loaded 16 tons), 1000KG/IB barrels (a small cabinet loaded 18 tons or 23 tons of ISOTANK).


Process scheme, under the condition of the reflux by recrystallization sertraline - imine purified. For this, will be dissolved in a suitable alcohol Sertralon (usually contains 2-10% and 0.01 0.3% sulfonic acid) pure isomer of sertraline - imine advance into a suitable reaction vessel with stirrer and reflux cooler. Reaction material in the inert atmosphere and under the condition of stirring heated to reflux temperature, until we get a clear solution.

The solution to the corresponding separation temperature, cooling products slowly precipitate out of it. To filter the suspension, solvent filter cake washing and drying. Imine yield was 80-90%, Sertralon content is 0.1 0.3% (HPLC), content of catalyst 0.001, or less water content is 0.1 0.3%.

Under stress conditions sertraline - imine recrystallization. To this end, the pressure of a suitable zone mixer reactor in unprocessed sertraline - imine and a solvent in advance. Response for nitrogen inerting and seal. Begin to stir, and heat the reaction mixture to the desired reaction temperature, until we get a clear solution. The solution to the corresponding separation temperature, cooling products slowly precipitate out of it. To filter the suspension, solvent filter cake washing and drying.

The selected alcohol solution temperature in the range of 50-150 ℃, optimization of 70-140 ℃. The imine containing 5% water Sertralon0.1%18 cases without catalyst preparation of sertraline - imine recrystallization under the condition of adding 480 mg of activated carbon to make implementation of 16 cases of imine recrystallization. Back after 1 hour hot clear filtration (T > 70 ℃), and then cooling.

Get the following results 88% yield of sertraline - imine the imine containing 0.2% Sertralon < 0.05% water example 19 above the boiling point temperature (pressure) make sertraline - imine in ethanol recrystallization will implementation of the 10 g soluble in 20 ml of ethanol in 18 sertraline - imine advance into a suitable reaction tank with agitator. Under the condition of stirring reaction mixture is heated to 110-115 ℃ (pressure range of 2-5), until a clear solution. Will slowly cooling solution to 20 ℃, and at the same time product precipitation. To filter the suspension, solvent washing filter cake, and dry.

Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd 

Diethyl toluene diamine(DETDA)  http://www.yaruichem.com