News Details
Injection of antioxidants
2018-1-6 12:17:56
Injection of antioxidants
If the injection is not prevented from oxidation during the preparation process, it may affect the therapeutic effect of the main drug, and may even produce more related substances to increase the risk of adverse reactions. Therefore, in order to ensure the quality of the drug and increase the stability of the drug, it is necessary to choose the appropriate anti-oxygen agent for injection.
Vitamin C in vitamin C injection is a multiple hydroxyl ketones acid lactone, as a strong reductant, easy oxidative damage by light, heat, oxygen, to effectively prevent the oxidation, effective injection antioxidants may be added. Antioxidant sodium metabisulfite to improve vitamin C injection caused by the oxidation of color change has good effect, can effectively inhibit the oxidation of vitamin C, degradation, discoloration, make vitamin C injection is stable.
And the bases of the puerarin injection puerarin and its chemical name is 8 - beta - D - pyridine grape sugar - 4, 7 - dihydroxy isoflavones, due to its structure containing phenol hydroxyl, easily lead to its property is not stable, oxidized pH down sharply in the process of storage, yellow color, content also decreased, so on the basis of the original prescription with concentration of 1% thiourea as an antioxidant, can make the pH value, stable color and content.
Sodium metabisulfite is white or yellow crystalline powder or small crystals, with a strong smell of SO2, specific gravity 1.4, soluble in water, acidic aqueous solution, contact with strong acid is released SO2 and generate the corresponding salts, for a long time in the air, is oxidized to Na2S2O6, so the product cannot be far. It's higher than 150 degrees Celsius, which is the decomposition of SO2.
The name of the English name: disodiummetabisulfite; Disodiumpyrosulphite; Fertisilo; Metabisulfitedesodium; Sodiummetabisufite; Sodiummetabisulfite (na2 - s2o5); Sodiumpyrosulfite (na2s2o5); Sodium dissulfite; Sodium disulphite; Sodium pyrosulphite
Sodium bisulfite: sodium bisulfite; Sodium disulfite; Sulfur heavy oxygen; Sodium sulfite; Sodium bisulfite; Sodium pyrosulfite; Eat jiao sulfite.
Triphenyl phosphite (antioxidant, stabilizer TPPi)
Packing method: net weight of 200KG/galvanized iron bucket (a small cabinet to hold 16 tons), 1000KG/IB (a small container with 18 tons) or 23 tons of it.
Port of shipment: Shanghai port
Price quotation validity: 15 days
Warehouse time: within 15 days (customs clearance)
Export rights: our own right to import and export.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
Sodium pyrosulfite is white or yellowish crystalline powder or crystallization; Sulfur dioxide is more than 65 %; Iron is 0.005% or less; Water insoluble substance is less than 0.05%; PH value: 4.0-4.6.
Sodium pyrosulfite; Sodium bisulfite; Sulfur heavy oxygen; Sodium metabisulfite. Sodium pyrosulfite molecular formula Na2S2O5; The molecular weight of 190.10
; A colorless prismatic crystal or white powder; Sulfur dioxide, acid, salt; Store the color gradient yellow. Melting point (℃) : > 300 (decomposition); Relative density (water = 1) : 1.48; Solubility: soluble in water, acidic aqueous solution (20 ℃ for 54 g / 100 ml water. At 100 ℃ for 81.7 g / 100 ml water). Soluble in glycerol, slightly soluble in ethanol. Relative density 1.4. Water soluble in glycerin and slightly soluble in ethanol. The moisture is easy to break down, and the exposed air is easily oxidized to sodium sulfate. The contact with the strong acid emits sulfur dioxide and produces the corresponding salts. Heated to 150 ℃.
Sodium pyrosulfite: strong acid and strong oxidant. The condition for avoiding contact with sodium pyrosulfite: humid air.
Thiourea is a white, shiny crystal. Bitter taste. The density of 1.41. The melting point of 176 ~ 178 ℃. It breaks down even hotter. Soluble in water, soluble in ethanol when heated, and very slightly soluble in ether. In the melting time it is partially isomerized to form thiocyanate. Used in the manufacture of raw materials such as drugs, dyes, resins, plasticizers, etc., as well as rubber vulcanization promoters, metal mineral flotation agents, etc. Hydrogen sulfide and lime slurry are used to form calcium hydrogenated calcium, and then with cyanide (base) calcium. It can also be used to make ammonium thiocyanate, or cyanide and hydrogen sulphide.
Thiourea melting point (℃) : 176 ~ 178; Relative density (water = 1) : 1.41; Boiling point (℃) : decomposition; Molecular formula: CH4N2S; Molecular weight: 76.12; Value of octanol/water distribution coefficient: 2.5; Solubility: soluble in cold water and ethanol and slightly soluble in ether.
Thiourea is in flame and high heat. Thermal decomposition, releasing nitrogen, sulfur oxide and other toxic gases. It reacts strongly with the oxidant.
In the air the deliquescence. At 150 ℃ into ammonium thiocyanate. During 150-160 ℃ under vacuum sublimation, 180 ℃ when the decomposition. It has the reductive ability, can make the deionized iodine reduced to iodide.
Thiourea is highly reactive and used to prepare various compounds. It can react with many kinds of oxidants to form urea, sulfuric acid and other organic compounds, and can be made into soluble compounds with inorganic compounds.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
If the injection is not prevented from oxidation during the preparation process, it may affect the therapeutic effect of the main drug, and may even produce more related substances to increase the risk of adverse reactions. Therefore, in order to ensure the quality of the drug and increase the stability of the drug, it is necessary to choose the appropriate anti-oxygen agent for injection.
Vitamin C in vitamin C injection is a multiple hydroxyl ketones acid lactone, as a strong reductant, easy oxidative damage by light, heat, oxygen, to effectively prevent the oxidation, effective injection antioxidants may be added. Antioxidant sodium metabisulfite to improve vitamin C injection caused by the oxidation of color change has good effect, can effectively inhibit the oxidation of vitamin C, degradation, discoloration, make vitamin C injection is stable.
And the bases of the puerarin injection puerarin and its chemical name is 8 - beta - D - pyridine grape sugar - 4, 7 - dihydroxy isoflavones, due to its structure containing phenol hydroxyl, easily lead to its property is not stable, oxidized pH down sharply in the process of storage, yellow color, content also decreased, so on the basis of the original prescription with concentration of 1% thiourea as an antioxidant, can make the pH value, stable color and content.
Sodium metabisulfite is white or yellow crystalline powder or small crystals, with a strong smell of SO2, specific gravity 1.4, soluble in water, acidic aqueous solution, contact with strong acid is released SO2 and generate the corresponding salts, for a long time in the air, is oxidized to Na2S2O6, so the product cannot be far. It's higher than 150 degrees Celsius, which is the decomposition of SO2.
The name of the English name: disodiummetabisulfite; Disodiumpyrosulphite; Fertisilo; Metabisulfitedesodium; Sodiummetabisufite; Sodiummetabisulfite (na2 - s2o5); Sodiumpyrosulfite (na2s2o5); Sodium dissulfite; Sodium disulphite; Sodium pyrosulphite
Sodium bisulfite: sodium bisulfite; Sodium disulfite; Sulfur heavy oxygen; Sodium sulfite; Sodium bisulfite; Sodium pyrosulfite; Eat jiao sulfite.
Triphenyl phosphite (antioxidant, stabilizer TPPi)
Packing method: net weight of 200KG/galvanized iron bucket (a small cabinet to hold 16 tons), 1000KG/IB (a small container with 18 tons) or 23 tons of it.
Port of shipment: Shanghai port
Price quotation validity: 15 days
Warehouse time: within 15 days (customs clearance)
Export rights: our own right to import and export.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
Sodium pyrosulfite is white or yellowish crystalline powder or crystallization; Sulfur dioxide is more than 65 %; Iron is 0.005% or less; Water insoluble substance is less than 0.05%; PH value: 4.0-4.6.
Sodium pyrosulfite; Sodium bisulfite; Sulfur heavy oxygen; Sodium metabisulfite. Sodium pyrosulfite molecular formula Na2S2O5; The molecular weight of 190.10
; A colorless prismatic crystal or white powder; Sulfur dioxide, acid, salt; Store the color gradient yellow. Melting point (℃) : > 300 (decomposition); Relative density (water = 1) : 1.48; Solubility: soluble in water, acidic aqueous solution (20 ℃ for 54 g / 100 ml water. At 100 ℃ for 81.7 g / 100 ml water). Soluble in glycerol, slightly soluble in ethanol. Relative density 1.4. Water soluble in glycerin and slightly soluble in ethanol. The moisture is easy to break down, and the exposed air is easily oxidized to sodium sulfate. The contact with the strong acid emits sulfur dioxide and produces the corresponding salts. Heated to 150 ℃.
Sodium pyrosulfite: strong acid and strong oxidant. The condition for avoiding contact with sodium pyrosulfite: humid air.
Thiourea is a white, shiny crystal. Bitter taste. The density of 1.41. The melting point of 176 ~ 178 ℃. It breaks down even hotter. Soluble in water, soluble in ethanol when heated, and very slightly soluble in ether. In the melting time it is partially isomerized to form thiocyanate. Used in the manufacture of raw materials such as drugs, dyes, resins, plasticizers, etc., as well as rubber vulcanization promoters, metal mineral flotation agents, etc. Hydrogen sulfide and lime slurry are used to form calcium hydrogenated calcium, and then with cyanide (base) calcium. It can also be used to make ammonium thiocyanate, or cyanide and hydrogen sulphide.
Thiourea melting point (℃) : 176 ~ 178; Relative density (water = 1) : 1.41; Boiling point (℃) : decomposition; Molecular formula: CH4N2S; Molecular weight: 76.12; Value of octanol/water distribution coefficient: 2.5; Solubility: soluble in cold water and ethanol and slightly soluble in ether.
Thiourea is in flame and high heat. Thermal decomposition, releasing nitrogen, sulfur oxide and other toxic gases. It reacts strongly with the oxidant.
In the air the deliquescence. At 150 ℃ into ammonium thiocyanate. During 150-160 ℃ under vacuum sublimation, 180 ℃ when the decomposition. It has the reductive ability, can make the deionized iodine reduced to iodide.
Thiourea is highly reactive and used to prepare various compounds. It can react with many kinds of oxidants to form urea, sulfuric acid and other organic compounds, and can be made into soluble compounds with inorganic compounds.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
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