News Details
Antioxidants for pharmaceutical preparations
2018-1-3 12:03:12
Antioxidants for pharmaceutical preparations
Some components in external preparation are easily oxidized, which are often oxidized in the preparation and storage process, which leads to the deepening of the preparation color and the quality of the preparation. Therefore, in the preparation process, the antioxidant of drug preparation should be added to delay the oxidation of the main drug and improve the quality of the preparation.
Sodium pyrosulfite is dehydrated by two molecule Sodium Bisulfite. In aqueous solution, bisulfite can be hydrolyzed to bisulfite, while bisulfite can be oxidized easily. It can be used as an antioxidant for many pharmaceutical preparations.
Compound resorcinol lotion is a topical lotion by resorcinol, phenol, boric acid and other liquefied ingredients, the resorcinol molecular structure contains 2 phenolic hydroxyl groups, has the strong reducibility, easily oxidized to quinone coloured substances, the lotion is yellow, brown or red brown, which not only reduces the ability of sterilization, but also affect the quality of the finished product. If adding 0.2% Sodium Bisulfite or sodium pyrosulfite into the original prescription as antioxidants of compound resorcinol lotion, it can significantly inhibit the oxidation and discoloration of resorcinol, ensure the appearance and quality of its finished products, and increase the stability of its preparations.
Red paste in safflower kernel containing safflor yellow, red pigment, structure of the two kinds of pigments containing phenolic hydroxyl, temperature and light will make the hydroxyl oxidation, the oxidation of discoloration during storage, if the addition of antioxidant drugs in the prescription of Sodium Bisulfite, can prevent or delay the oxidation phenomenon, thereby increasing the stability of the ointment.
Sodium metabisulfite is white or yellow crystalline powder or small crystal, with a strong smell of SO2, the proportion of 1.4, soluble in water, acidic aqueous solution, contact with strong acids released SO2 and generates the corresponding salts, long in the air, is oxidized to Na2S2O6, so the product can not be stored for a long time. Higher than 150 degrees Celsius, that is, the decomposition of SO2.
Sodium pyrosulfite; heavy sodium sulfite; disulfide; Sodium metabisulfite; Sodium pyrosulfite molecular Na2S2O5; molecular weight 190.10
Appearance and character: colorless prism crystalline or white powder; sulfur dioxide, acid, salty; storage of a long color gradually yellow.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
Cas no. : 101-02-0
HS: 29209019.00
The most important index of products: colorless, yellow liquid
Density (rho) 2525:1.183-1.192, refractive index (eta 020) : 1.585 1.590, freezing point ° C: 19-24, chloride (Cl - %) : 0.20 or less
Tax refund: the current tax refund of Triphenyl phosphite is 9 percent
Raw materials: phenol, phosphorus trichloride, phosphorus trichloride.
Sodium pyrosulfite melting point (temperature): >300 (decomposition); relative density (water =1): 1.48; solubility: dissolved in water, aqueous solution is acidic (54g/100ml water at 20 degrees centigrade, 81.7g/100ml water at 100 degrees centigrade). Soluble in glycerol and slightly soluble in ethanol. The relative density is 1.4. Soluble in water soluble in glycerin, slightly soluble in ethanol. The moisture is easily decomposed, and it is easily oxidized to sodium sulfate in the exposed air. Contact with strong acid to release sulfur dioxide and produce the corresponding salts. Heat up to 150 degrees centigrade.
There are two technological routes for the production of sodium pyrosulfite, which are dry and wet.
(1) dry law. The soda and water were stirred evenly at a certain molar ratio. When the Na2CO3.nH2O was massive, it was put into the reactor. There was a certain gap between the block and the block. Then the SO2 was inserted until the end of the reaction. The blocky product was removed and the product was crushed.
(2) wet method. In Sodium Bisulfite solution, a certain amount of soda ash was added to make sodium sulfite suspension. Then it was added to SO2, that is, sodium pyrosulfite crystal was formed. After centrifugation and drying, the product was obtained.
Sodium Bisulfite, white crystalline powder. It has the odor of sulfur dioxide and is unpleasant. The exposed air loses some of the sulfur dioxide and oxidizes it to sulphate. It dissolves in 3.5 portions of cold water, 2 boiling water and about 70 ethanol, and its aqueous solution is acidic.
Sodium Bisulfite, dissolved in 3.5 portions of cold water, 2 boiling water and about 70 ethanol, is acidic in its aqueous solution. Melting point decomposition. The relative density is 1.48. Low toxicity, median lethal dose (rat, oral) 2000mg/kg. It's exciting. Commodities often contain a variety of proportions of sodium sulfite (Na2S2O5).
Preparation of Sodium Bisulfite sample: iodine titrant (0.05mol/L)
Preparation: Taking iodine 13.0g, potassium iodide 36g and water 50mL dissolved, add 3 drops of hydrochloric acid and water to make 1000mL, shake well and filter through the vertical glass filter.
Calibration: take 105 C in the benchmark of arsenic trioxide is dried to constant weight of about 0.15g, precision said, adding sodium hydroxide titration solution (1mol/L 10mL), heat to dissolve, add 20mL of water and 1 drops of methyl orange indicator liquid, adding sulfuric acid titration solution (0.5mol/L) the amount of the yellow to pink, add 2G of sodium bicarbonate, water and 50mL starch indicator solution 2mL, the solution titration solution to pale blue purple. Every 1mL iodine titrant (0.05mol/L) is equivalent to arsenic trioxide of 4.946mg. According to the consumption of this liquid and the amount of arsenic trioxide, the concentration of the liquid is calculated.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
Some components in external preparation are easily oxidized, which are often oxidized in the preparation and storage process, which leads to the deepening of the preparation color and the quality of the preparation. Therefore, in the preparation process, the antioxidant of drug preparation should be added to delay the oxidation of the main drug and improve the quality of the preparation.
Sodium pyrosulfite is dehydrated by two molecule Sodium Bisulfite. In aqueous solution, bisulfite can be hydrolyzed to bisulfite, while bisulfite can be oxidized easily. It can be used as an antioxidant for many pharmaceutical preparations.
Compound resorcinol lotion is a topical lotion by resorcinol, phenol, boric acid and other liquefied ingredients, the resorcinol molecular structure contains 2 phenolic hydroxyl groups, has the strong reducibility, easily oxidized to quinone coloured substances, the lotion is yellow, brown or red brown, which not only reduces the ability of sterilization, but also affect the quality of the finished product. If adding 0.2% Sodium Bisulfite or sodium pyrosulfite into the original prescription as antioxidants of compound resorcinol lotion, it can significantly inhibit the oxidation and discoloration of resorcinol, ensure the appearance and quality of its finished products, and increase the stability of its preparations.
Red paste in safflower kernel containing safflor yellow, red pigment, structure of the two kinds of pigments containing phenolic hydroxyl, temperature and light will make the hydroxyl oxidation, the oxidation of discoloration during storage, if the addition of antioxidant drugs in the prescription of Sodium Bisulfite, can prevent or delay the oxidation phenomenon, thereby increasing the stability of the ointment.
Sodium metabisulfite is white or yellow crystalline powder or small crystal, with a strong smell of SO2, the proportion of 1.4, soluble in water, acidic aqueous solution, contact with strong acids released SO2 and generates the corresponding salts, long in the air, is oxidized to Na2S2O6, so the product can not be stored for a long time. Higher than 150 degrees Celsius, that is, the decomposition of SO2.
Sodium pyrosulfite; heavy sodium sulfite; disulfide; Sodium metabisulfite; Sodium pyrosulfite molecular Na2S2O5; molecular weight 190.10
Appearance and character: colorless prism crystalline or white powder; sulfur dioxide, acid, salty; storage of a long color gradually yellow.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
Cas no. : 101-02-0
HS: 29209019.00
The most important index of products: colorless, yellow liquid
Density (rho) 2525:1.183-1.192, refractive index (eta 020) : 1.585 1.590, freezing point ° C: 19-24, chloride (Cl - %) : 0.20 or less
Tax refund: the current tax refund of Triphenyl phosphite is 9 percent
Raw materials: phenol, phosphorus trichloride, phosphorus trichloride.
Sodium pyrosulfite melting point (temperature): >300 (decomposition); relative density (water =1): 1.48; solubility: dissolved in water, aqueous solution is acidic (54g/100ml water at 20 degrees centigrade, 81.7g/100ml water at 100 degrees centigrade). Soluble in glycerol and slightly soluble in ethanol. The relative density is 1.4. Soluble in water soluble in glycerin, slightly soluble in ethanol. The moisture is easily decomposed, and it is easily oxidized to sodium sulfate in the exposed air. Contact with strong acid to release sulfur dioxide and produce the corresponding salts. Heat up to 150 degrees centigrade.
There are two technological routes for the production of sodium pyrosulfite, which are dry and wet.
(1) dry law. The soda and water were stirred evenly at a certain molar ratio. When the Na2CO3.nH2O was massive, it was put into the reactor. There was a certain gap between the block and the block. Then the SO2 was inserted until the end of the reaction. The blocky product was removed and the product was crushed.
(2) wet method. In Sodium Bisulfite solution, a certain amount of soda ash was added to make sodium sulfite suspension. Then it was added to SO2, that is, sodium pyrosulfite crystal was formed. After centrifugation and drying, the product was obtained.
Sodium Bisulfite, white crystalline powder. It has the odor of sulfur dioxide and is unpleasant. The exposed air loses some of the sulfur dioxide and oxidizes it to sulphate. It dissolves in 3.5 portions of cold water, 2 boiling water and about 70 ethanol, and its aqueous solution is acidic.
Sodium Bisulfite, dissolved in 3.5 portions of cold water, 2 boiling water and about 70 ethanol, is acidic in its aqueous solution. Melting point decomposition. The relative density is 1.48. Low toxicity, median lethal dose (rat, oral) 2000mg/kg. It's exciting. Commodities often contain a variety of proportions of sodium sulfite (Na2S2O5).
Preparation of Sodium Bisulfite sample: iodine titrant (0.05mol/L)
Preparation: Taking iodine 13.0g, potassium iodide 36g and water 50mL dissolved, add 3 drops of hydrochloric acid and water to make 1000mL, shake well and filter through the vertical glass filter.
Calibration: take 105 C in the benchmark of arsenic trioxide is dried to constant weight of about 0.15g, precision said, adding sodium hydroxide titration solution (1mol/L 10mL), heat to dissolve, add 20mL of water and 1 drops of methyl orange indicator liquid, adding sulfuric acid titration solution (0.5mol/L) the amount of the yellow to pink, add 2G of sodium bicarbonate, water and 50mL starch indicator solution 2mL, the solution titration solution to pale blue purple. Every 1mL iodine titrant (0.05mol/L) is equivalent to arsenic trioxide of 4.946mg. According to the consumption of this liquid and the amount of arsenic trioxide, the concentration of the liquid is calculated.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
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