News Details
Antioxidants for medicine
2018-1-4 23:53:00
Antioxidants for medicine
During a long period of storage, the drug also has a slow oxidation degradation reaction, which produces degradation substances, thus affecting the quality of the drug. Glucose infusion during storage, the toxic degradation products of 5- hydroxymethyl furfural (5-HMF), the influence of transfusion quality, if in the production process by adding antioxidant medicine with Sodium Bisulfite, can effectively prevent the oxidative degradation, prevent 5- hydroxymethyl furfural production, and have no effect on the infusion of clarity and color.
Simvastatin Tablets is the second generation of strong effective HMG-CoA reductase inhibitors, and is one of the best drugs for hypercholesterolemia. But because of its structure does not exist in the stable group of 4- hydroxy -6 oxygenation -2H pyran ring, easily oxidized, selecting appropriate antioxidant, if citrate added 0.3% ANISOL and 0.2% in its prescription in combination or use 0.5% ANISOL alone antioxidant used as medicine, can improve the storage stability of the tablets in.
All substances that prevent oxidants or oxygen in the air from oxidizing drugs are called antioxidants. Medical antioxidants are a kind of substances that are easy to oxidize. After adding them to the solution of oxidizing drugs, the antioxidants of medicine can first be oxidized to maintain the stability of drugs.
The requirements for antioxidants for medicine are:
(1) there is no physiological activity, which does not affect the therapeutic effect of the drug.
(2) the antioxygen effect is strong and durable, and its standard oxidation potential should be greater than the protected drug, and it should be a more stable substance.
(3) high purity to prevent the possible presence of oxidizing catalysts such as metal ions. Many drugs are easy to change, decompose, precipitate or increase the toxicity and the efficacy of the drug when they are prepared.
In order to maintain the efficacy of drug preparations, the liquid will not change color and keep the original clarity and evenness. It is necessary to choose suitable antioxidants according to the chemical structure and physicochemical properties of the main drugs. For example, Adrealine Injection and sodium pyrosulphate 0.1%.
Triphenyl phosphite (antioxidant, stabilizer TPPi)
Packing method: net weight of 200KG/galvanized iron bucket (a small cabinet to hold 16 tons), 1000KG/IB (a small container with 18 tons) or 23 tons of it.
Port of shipment: Shanghai port
Price quotation validity: 15 days
Warehouse time: within 15 days (customs clearance)
Export rights: our own right to import and export.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
The utility and importance of antioxidants is one of the processes that destroy drugs. In vitro (pharmaceutical formulations) and in vivo (biological metabolism) can destroy the drugs. Although in vitro oxidation involves the participation of oxygen, most of the biological oxidation occurs under anoxic condition, because the oxidation is actually a dehydrogenation action. So when a compound is removed from a pair of hydrogen atoms, it is oxidized.
Antioxidants are an important part of pharmaceutical excipients. They are mainly used to prevent oxidation and deterioration of drugs and their preparations, as well as the discoloration, precipitation and other aspects caused by oxidation. The oxidation of drugs is one of the main factors that cause drug instability.
The oxidative degradation of most drugs is a self oxidation process containing free radicals, in which only a small amount of oxygen can cause reaction. The oxygen in the air accounts for 21% (v/v). In the presence of so much oxygen, the drug does not need other oxidants to participate. At room temperature, it can spontaneously cause "self oxidation reaction".
The reaction process is very complex. It belongs to the chain reaction induced by free radicals. Light and heat energy accelerate this reaction. Trace metal ions or peroxide will also catalyze this reaction. In the preparation of effective components such as phenol hydroxyl or potential phenol hydroxyl in molecular structure, as long as a small amount of oxygen exists, it may cause the self oxidation reaction of the drug.
The result of drug oxidation not only reduces the content of effective substances, but also changes the color of drugs, precipitates, and even produces toxic substances, which affect the quality of preparations.
Therefore, in order to inhibit the effect of O2 on the oxidation reaction, it is necessary to add antioxidants. Antioxidant is itself a reducing agent. When it is in the presence of drugs at the same time, antioxidants will first be oxidized after oxygen, which will protect the components that are easy to oxidize, so as to ensure the stability of pharmaceutical preparations. In the process of self oxidation, the antioxidant function is to provide electronic or effective hydrogen ions, to supply free radicals to accept, and to break the reaction of the self oxidation chain. At present, antioxidants have been widely used in medicine and have developed rapidly.
At present, the development and utilization of antioxidants have been widely used. Considering the long development of the medical science, we should strengthen the research on the basic theory of the pharmaceutical antioxidant. The antioxidant activity of various antioxidants is not only related to their chemical structure, but also related to many factors, such as temperature, dissolution and dispersing ability and synergistic effect. The development and use of pharmaceutical antioxidants must be considered and optimized. Strengthen the research and development of compound antioxidant.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
During a long period of storage, the drug also has a slow oxidation degradation reaction, which produces degradation substances, thus affecting the quality of the drug. Glucose infusion during storage, the toxic degradation products of 5- hydroxymethyl furfural (5-HMF), the influence of transfusion quality, if in the production process by adding antioxidant medicine with Sodium Bisulfite, can effectively prevent the oxidative degradation, prevent 5- hydroxymethyl furfural production, and have no effect on the infusion of clarity and color.
Simvastatin Tablets is the second generation of strong effective HMG-CoA reductase inhibitors, and is one of the best drugs for hypercholesterolemia. But because of its structure does not exist in the stable group of 4- hydroxy -6 oxygenation -2H pyran ring, easily oxidized, selecting appropriate antioxidant, if citrate added 0.3% ANISOL and 0.2% in its prescription in combination or use 0.5% ANISOL alone antioxidant used as medicine, can improve the storage stability of the tablets in.
All substances that prevent oxidants or oxygen in the air from oxidizing drugs are called antioxidants. Medical antioxidants are a kind of substances that are easy to oxidize. After adding them to the solution of oxidizing drugs, the antioxidants of medicine can first be oxidized to maintain the stability of drugs.
The requirements for antioxidants for medicine are:
(1) there is no physiological activity, which does not affect the therapeutic effect of the drug.
(2) the antioxygen effect is strong and durable, and its standard oxidation potential should be greater than the protected drug, and it should be a more stable substance.
(3) high purity to prevent the possible presence of oxidizing catalysts such as metal ions. Many drugs are easy to change, decompose, precipitate or increase the toxicity and the efficacy of the drug when they are prepared.
In order to maintain the efficacy of drug preparations, the liquid will not change color and keep the original clarity and evenness. It is necessary to choose suitable antioxidants according to the chemical structure and physicochemical properties of the main drugs. For example, Adrealine Injection and sodium pyrosulphate 0.1%.
Triphenyl phosphite (antioxidant, stabilizer TPPi)
Packing method: net weight of 200KG/galvanized iron bucket (a small cabinet to hold 16 tons), 1000KG/IB (a small container with 18 tons) or 23 tons of it.
Port of shipment: Shanghai port
Price quotation validity: 15 days
Warehouse time: within 15 days (customs clearance)
Export rights: our own right to import and export.
Triphenyl phosphite (TPPi antioxidants, stabilizer) is mainly used in PVC, polyethylene, polypropylene, polystyrene, polyester, abs resin, epoxy resin, synthetic rubber antioxidant stabilizer, used in polyvinyl chloride (PVC) products as a chelating agent.
The utility and importance of antioxidants is one of the processes that destroy drugs. In vitro (pharmaceutical formulations) and in vivo (biological metabolism) can destroy the drugs. Although in vitro oxidation involves the participation of oxygen, most of the biological oxidation occurs under anoxic condition, because the oxidation is actually a dehydrogenation action. So when a compound is removed from a pair of hydrogen atoms, it is oxidized.
Antioxidants are an important part of pharmaceutical excipients. They are mainly used to prevent oxidation and deterioration of drugs and their preparations, as well as the discoloration, precipitation and other aspects caused by oxidation. The oxidation of drugs is one of the main factors that cause drug instability.
The oxidative degradation of most drugs is a self oxidation process containing free radicals, in which only a small amount of oxygen can cause reaction. The oxygen in the air accounts for 21% (v/v). In the presence of so much oxygen, the drug does not need other oxidants to participate. At room temperature, it can spontaneously cause "self oxidation reaction".
The reaction process is very complex. It belongs to the chain reaction induced by free radicals. Light and heat energy accelerate this reaction. Trace metal ions or peroxide will also catalyze this reaction. In the preparation of effective components such as phenol hydroxyl or potential phenol hydroxyl in molecular structure, as long as a small amount of oxygen exists, it may cause the self oxidation reaction of the drug.
The result of drug oxidation not only reduces the content of effective substances, but also changes the color of drugs, precipitates, and even produces toxic substances, which affect the quality of preparations.
Therefore, in order to inhibit the effect of O2 on the oxidation reaction, it is necessary to add antioxidants. Antioxidant is itself a reducing agent. When it is in the presence of drugs at the same time, antioxidants will first be oxidized after oxygen, which will protect the components that are easy to oxidize, so as to ensure the stability of pharmaceutical preparations. In the process of self oxidation, the antioxidant function is to provide electronic or effective hydrogen ions, to supply free radicals to accept, and to break the reaction of the self oxidation chain. At present, antioxidants have been widely used in medicine and have developed rapidly.
At present, the development and utilization of antioxidants have been widely used. Considering the long development of the medical science, we should strengthen the research on the basic theory of the pharmaceutical antioxidant. The antioxidant activity of various antioxidants is not only related to their chemical structure, but also related to many factors, such as temperature, dissolution and dispersing ability and synergistic effect. The development and use of pharmaceutical antioxidants must be considered and optimized. Strengthen the research and development of compound antioxidant.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
http://www.yaruichem.com
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