News Details
Anine ester coating crosslinking agent
2017-5-13 13:29:12
Anine ester coating crosslinking agent,It can form an amide bond with the beramide reaction. The formed amide bonds are protonised, so they have a positive charge under the physiological pH. Imide acid esters with bifunctional crosslinking agent used in protein molecular structure, the membrane surface molecular interactions, and protein molecular fixed the solid surface.
In addition, the crosslinking agent of the anine ester can also be used as a substitute for glutaraldehyde for tissue fixation. Imide acid esters of crosslinking agent is free to appear a cell membrane, so can be crosslinked membrane proteins, membrane composition, structure, and protein, protein, lipid and protein interaction.
Such crosslinking agents can also be used to study the number and positioning of different subunits within the multiple subgroup. In this reaction, excessive crosslinking agents (100 to 1000 times) and low concentrations of protein (< 1mg/ml) are commonly used to improve the crosslinking efficiency within the molecule.
It can react quickly with the amino group in alkaline conditions, but its half-life is short. If the pH increases, the half-life and amino reactivity will also increase. So, in the case of pH10, it's more efficient than pH8.
Chinese name: Diethyl toluene diamine(DETDA)
Chinese alias: aryl, aryl diethyl - aryl - methyl-p-phenylenediamine
English name: Benzenediamine, ar, ar-diethyl-ar-methyl-English aliases:Diethyltoluenediamine; ar, ar-Diethyl-ar-methylbenzenediamine;Diethylmethylbenzenediamine;
CAS No. :68479-98-1
EINECS No. :270 -877-4
Molecular formula: C11H18N2
Molecular Weight: 178.28
Boiling point: 310 ℃
Refractive index: 1.581
Flash Point: > 140 ℃
Inchi: InChI = 1/C11H18N2/c1-4-8-6-7 (3) 10 (12) 11 (13) 9 (8) 5-2/h6H ,4-5,12-13H2 ,1-3H3 density : 1.022
Risk Codes: R10; R35
RIDADR: UN 3082
Safety instructions: S2; S26; S39; S61
Packing Group: III
Hazard Class: 6.1
Although the optimum condition for an amide bond is ph8-10, it is easy to have a side reaction when the pH is below 10. The study of single-functional alkylmethylamide showed that when pH was less than 10, the crosslinking reaction occurred only on an anine ester group.
Intermediate N - alkane heartland of amine ester under the condition of low pH value formation, formation will react with adjacent amino N, N + - amide derivative, eventually the derivatives can also be forming amide bond and other by-products. When pH value is more than 10, the amino acid ester crosslinking agent of amide bond can be broken, so as to seek more effective and stable has been in the cross-linking effect of the NHS ester crosslinking agent.
Derivatives of the amino acid, the structure of the RL: (= : YH) CfH. Imide acid is highly stable compounds, very easily into phthalein amine Rt: (RI - I] OH ~ ~ RC '(VH =). But stable industry glycine vinegar, can exist independently.
Subamination is a more active group that can produce many chemical reactions. Heating is decomposed into cyanide and alcohol, or generate V a alkyl amine acid Rf ` {0 nef) CR}.} fZC (NfIR}) - O. Generated by hydrolysis of phenol and ammonia, acid casein of hydrochloride acid react with alcohol to generate the original cool, preparation of force method. (1) phthalein amine in the silver oxide F and halogenated reaction, (2) the cyanide reaction with alcohol, and (3) acid amine chloride with cool reaction, etc. Used as a reagent in organic synthesis.
Crosslinking agents are mainly used in polymer materials (rubber and thermosetting resin). Because the molecular structure of the polymer materials as one long line, not crosslinked intensity at the low, easy to break, and there is no elastic, the effect of crosslinking agent is to produce chemical bonds between the molecules of the form, the linear molecules each other together, form a mesh structure, increase strength and flexibility of the rubber, rubber crosslinking agent is mainly used in the sulfur, in addition to promoter.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
Diethyl toluene diamine(DETDA) http://www.yaruichem.com
In addition, the crosslinking agent of the anine ester can also be used as a substitute for glutaraldehyde for tissue fixation. Imide acid esters of crosslinking agent is free to appear a cell membrane, so can be crosslinked membrane proteins, membrane composition, structure, and protein, protein, lipid and protein interaction.
Such crosslinking agents can also be used to study the number and positioning of different subunits within the multiple subgroup. In this reaction, excessive crosslinking agents (100 to 1000 times) and low concentrations of protein (< 1mg/ml) are commonly used to improve the crosslinking efficiency within the molecule.
It can react quickly with the amino group in alkaline conditions, but its half-life is short. If the pH increases, the half-life and amino reactivity will also increase. So, in the case of pH10, it's more efficient than pH8.
Chinese name: Diethyl toluene diamine(DETDA)
Chinese alias: aryl, aryl diethyl - aryl - methyl-p-phenylenediamine
English name: Benzenediamine, ar, ar-diethyl-ar-methyl-English aliases:Diethyltoluenediamine; ar, ar-Diethyl-ar-methylbenzenediamine;Diethylmethylbenzenediamine;
CAS No. :68479-98-1
EINECS No. :270 -877-4
Molecular formula: C11H18N2
Molecular Weight: 178.28
Boiling point: 310 ℃
Refractive index: 1.581
Flash Point: > 140 ℃
Inchi: InChI = 1/C11H18N2/c1-4-8-6-7 (3) 10 (12) 11 (13) 9 (8) 5-2/h6H ,4-5,12-13H2 ,1-3H3 density : 1.022
Risk Codes: R10; R35
RIDADR: UN 3082
Safety instructions: S2; S26; S39; S61
Packing Group: III
Hazard Class: 6.1
Although the optimum condition for an amide bond is ph8-10, it is easy to have a side reaction when the pH is below 10. The study of single-functional alkylmethylamide showed that when pH was less than 10, the crosslinking reaction occurred only on an anine ester group.
Intermediate N - alkane heartland of amine ester under the condition of low pH value formation, formation will react with adjacent amino N, N + - amide derivative, eventually the derivatives can also be forming amide bond and other by-products. When pH value is more than 10, the amino acid ester crosslinking agent of amide bond can be broken, so as to seek more effective and stable has been in the cross-linking effect of the NHS ester crosslinking agent.
Derivatives of the amino acid, the structure of the RL: (= : YH) CfH. Imide acid is highly stable compounds, very easily into phthalein amine Rt: (RI - I] OH ~ ~ RC '(VH =). But stable industry glycine vinegar, can exist independently.
Subamination is a more active group that can produce many chemical reactions. Heating is decomposed into cyanide and alcohol, or generate V a alkyl amine acid Rf ` {0 nef) CR}.} fZC (NfIR}) - O. Generated by hydrolysis of phenol and ammonia, acid casein of hydrochloride acid react with alcohol to generate the original cool, preparation of force method. (1) phthalein amine in the silver oxide F and halogenated reaction, (2) the cyanide reaction with alcohol, and (3) acid amine chloride with cool reaction, etc. Used as a reagent in organic synthesis.
Crosslinking agents are mainly used in polymer materials (rubber and thermosetting resin). Because the molecular structure of the polymer materials as one long line, not crosslinked intensity at the low, easy to break, and there is no elastic, the effect of crosslinking agent is to produce chemical bonds between the molecules of the form, the linear molecules each other together, form a mesh structure, increase strength and flexibility of the rubber, rubber crosslinking agent is mainly used in the sulfur, in addition to promoter.
Copyright: Zhang Jia Gang YaRui Chemical co.,Ltd
Diethyl toluene diamine(DETDA) http://www.yaruichem.com
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